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Protective effect of Actinidia arguta in MPTP-induced Parkinson’s disease model mice
https://kinjo.repo.nii.ac.jp/records/1234
https://kinjo.repo.nii.ac.jp/records/1234af0a9da0-1211-45da-a7ac-01069dbd8390
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2022-04-02 | |||||
| タイトル | ||||||
| タイトル | Protective effect of Actinidia arguta in MPTP-induced Parkinson’s disease model mice | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Actinidia arguta | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Parkinson’s disease | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Neuroprotection | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Kitamura, Yuki
× Kitamura, Yuki× Sakanashi, Mayuko× Ozawa, Azuki× Saeki, Yuri× Nakamura, Ayano× Hara, Yuiho× Saeki, Ken-ichi× Arimoto-Kobayashi, Sakae |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Parkinson’s disease (PD) is a neurodegenerative disease characterized by the progressive degeneration of dopaminergic neurons in the substantia nigra. Oxidative stress-induced neuronal death has been identified as one of the major causes of nigrostriatal degeneration in PD. The fruit of Actinidia arguta (A. arguta), known as sarunashi in Japan, has been reported to show beneficial health effects such as antioxidant, anti-inflammatory, anti-mutagenic, and anticholinergic effects. In this study, we investigated the neuroprotective effects of A. arguta in 1-methyl-4-phenyl-1,2,3,6-tetrahydropypridine (MPTP)-induced PD model mice. A. arguta juice was administered to 7-week-old C57BL/6J mice continuously for 10 days before the first MPTP injection. The degeneration of dopaminergic neurons in the substantia nigra was induced by MPTP (30 mg/kg, i. p.) once daily for five consecutive days. We found that the administration of A. arguta ameliorated MPTP-induced motor impairment and suppressed the MPTP-induced reductions of tyrosine hydroxylase-positive neurons and tyrosine hydroxylase protein expression in the substantia nigra. Our findings suggest that taking A. arguta could provide neuroprotection that delays or prevents the neurodegenerative process of PD. | |||||
| 書誌情報 |
Biochemical and Biophysical Research Communications 巻 555, p. 154-159, 発行日 2021 |
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| 出版者 | ||||||
| 出版者 | Elsevier | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0006-291X | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 33819745 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1016/j.bbrc.2021.03.116 | |||||
| 権利 | ||||||
| 権利情報 | エルゼビア社のグリーンオープンアクセス | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.sciencedirect.com/science/article/am/pii/S0006291X21005143 | |||||
| 関連名称 | 著者原稿版 | |||||
| リンク |
若いバイリンガル子供の言語間影響の考えられる原因としての統語論 : 語用論インターフェース 一つの議論
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