{"created":"2023-06-20T13:09:30.589644+00:00","id":1234,"links":{},"metadata":{"_buckets":{"deposit":"a02d8b74-732d-4690-ba21-a7ad6b6e6d00"},"_deposit":{"created_by":11,"id":"1234","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"1234"},"status":"published"},"_oai":{"id":"oai:kinjo.repo.nii.ac.jp:00001234","sets":["156:161"]},"author_link":["2078","2079","2080","2081","2082","2083","2084","2085"],"control_number":"1234","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"159","bibliographicPageStart":"154","bibliographicVolumeNumber":"555","bibliographic_titles":[{"bibliographic_title":"Biochemical and Biophysical Research Communications"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Parkinson’s disease (PD) is a neurodegenerative disease characterized by the progressive degeneration of dopaminergic neurons in the substantia nigra. Oxidative stress-induced neuronal death has been identified as one of the major causes of nigrostriatal degeneration in PD. The fruit of Actinidia arguta (A. arguta), known as sarunashi in Japan, has been reported to show beneficial health effects such as antioxidant, anti-inflammatory, anti-mutagenic, and anticholinergic effects. In this study, we investigated the neuroprotective effects of A. arguta in 1-methyl-4-phenyl-1,2,3,6-tetrahydropypridine (MPTP)-induced PD model mice. A. arguta juice was administered to 7-week-old C57BL/6J mice continuously for 10 days before the first MPTP injection. The degeneration of dopaminergic neurons in the substantia nigra was induced by MPTP (30 mg/kg, i. p.) once daily for five consecutive days. We found that the administration of A. arguta ameliorated MPTP-induced motor impairment and suppressed the MPTP-induced reductions of tyrosine hydroxylase-positive neurons and tyrosine hydroxylase protein expression in the substantia nigra. Our findings suggest that taking A. arguta could provide neuroprotection that delays or prevents the neurodegenerative process of PD.","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier"}]},"item_10001_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"33819745","subitem_relation_type_select":"PMID"}}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.bbrc.2021.03.116","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"著者原稿版"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.sciencedirect.com/science/article/am/pii/S0006291X21005143","subitem_relation_type_select":"URI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"エルゼビア社のグリーンオープンアクセス"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0006-291X","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kitamura, Yuki"}],"nameIdentifiers":[{"nameIdentifier":"2078","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sakanashi, Mayuko"}],"nameIdentifiers":[{"nameIdentifier":"2079","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ozawa, Azuki"}],"nameIdentifiers":[{"nameIdentifier":"2080","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Saeki, Yuri"}],"nameIdentifiers":[{"nameIdentifier":"2081","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakamura, Ayano"}],"nameIdentifiers":[{"nameIdentifier":"2082","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hara, Yuiho"}],"nameIdentifiers":[{"nameIdentifier":"2083","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Saeki, Ken-ichi"}],"nameIdentifiers":[{"nameIdentifier":"2084","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Arimoto-Kobayashi, Sakae"}],"nameIdentifiers":[{"nameIdentifier":"2085","nameIdentifierScheme":"WEKO"}]}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Actinidia arguta","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Parkinson’s disease","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Neuroprotection","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Protective effect of Actinidia arguta in MPTP-induced Parkinson’s disease model mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Protective effect of Actinidia arguta in MPTP-induced Parkinson’s disease model mice"}]},"item_type_id":"10001","owner":"11","path":["161"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-04-02"},"publish_date":"2022-04-02","publish_status":"0","recid":"1234","relation_version_is_last":true,"title":["Protective effect of Actinidia arguta in MPTP-induced Parkinson’s disease model mice"],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2023-12-02T04:56:05.074571+00:00"}